The anime's story, set in Maebashi City in Gunma Prefecture, is about the coming-of-age story of five high school girls. First year high school student Yuina Akagi lives an ordinary but unsatisfying everyday life. One day, a mysterious frog named Keroppe scouts her and four other girls to become the "Maebashi Witches." Suddenly, a room closet is connected to a mysterious space that brings the girls to a magical flower shop where they sing, dance, and make other people's wishes come true.